There are nine subtypes of influenza A virus neuraminidase (NA), N1 to N9. In addition, influenza B virus also contains NA, and there are two influenza virus NA-like molecules, N10 and N11, which were recently identified from bats. Crystal structures for all of these proteins have been solved, with the exception of N7, and there is no published report of N6, although a structure has been deposited in the Protein Data Bank. Here, we present the N7 and N6 structures at 2.1 Å and 1.8 Å, respectively. Structural comparison of all NA subtypes shows that both N7 and N6 highly resemble typical group 2 NA structures with some special char-acteristics, including an additional cavity adjacent to their active sites formed by novel 340-loop conformatio...
AbstractNeuraminidase (NA) is a homotetramer viral surface glycoprotein that is essential for virus ...
Influenza A viruses (IAVs) of the H1N1 and H3N2 serotypes are the major cause of seasonal influenza ...
Influenza A virus attachment to and release from sialoside receptors is determined by the balance be...
Influenza virus neuraminidase (NA) plays a crucial role in facilitating the spread of newly synthesi...
<div><p>The ability to identify the functional correlates of structural and sequence variation in pr...
Swine flu is a global pandemic disease caused by influenza A-type viruses.1 High-pathogenic flu viru...
The ability to identify the functional correlates of structural and sequence variation in proteins i...
The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the a...
The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) prot...
Influenza A viruses (IAVs) are one of the most common human respiratory pathogens and are largely re...
Hemagglutinin (HA) and neuraminidase (NA) are the two major surface proteins of influenza A virus (I...
Abstract Background Influenza neuraminidase (NA) is essential for virus release from its host cells ...
The viral surface glycoprotein neuraminidase (NA) allows the influenza virus penetration and the egr...
Influenza neuraminidase (NA) is an important surface glycoprotein and plays a vital role in viral re...
We have studied the maturation of the influenza A virus neuraminidase (NA), using monoclonal antibod...
AbstractNeuraminidase (NA) is a homotetramer viral surface glycoprotein that is essential for virus ...
Influenza A viruses (IAVs) of the H1N1 and H3N2 serotypes are the major cause of seasonal influenza ...
Influenza A virus attachment to and release from sialoside receptors is determined by the balance be...
Influenza virus neuraminidase (NA) plays a crucial role in facilitating the spread of newly synthesi...
<div><p>The ability to identify the functional correlates of structural and sequence variation in pr...
Swine flu is a global pandemic disease caused by influenza A-type viruses.1 High-pathogenic flu viru...
The ability to identify the functional correlates of structural and sequence variation in proteins i...
The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the a...
The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase (NA) prot...
Influenza A viruses (IAVs) are one of the most common human respiratory pathogens and are largely re...
Hemagglutinin (HA) and neuraminidase (NA) are the two major surface proteins of influenza A virus (I...
Abstract Background Influenza neuraminidase (NA) is essential for virus release from its host cells ...
The viral surface glycoprotein neuraminidase (NA) allows the influenza virus penetration and the egr...
Influenza neuraminidase (NA) is an important surface glycoprotein and plays a vital role in viral re...
We have studied the maturation of the influenza A virus neuraminidase (NA), using monoclonal antibod...
AbstractNeuraminidase (NA) is a homotetramer viral surface glycoprotein that is essential for virus ...
Influenza A viruses (IAVs) of the H1N1 and H3N2 serotypes are the major cause of seasonal influenza ...
Influenza A virus attachment to and release from sialoside receptors is determined by the balance be...